Development and application of a high-content virion display human GPCR array

Fabrication of a non-odorant VirD-GPCR array To develop the first high-content VirD array, we decided to focus on the 370 non-odorant GPCRs. We assembled a collection of open reading frames (ORFs) encoding 337 non-odorant GPCRs...

Human-gut-microbiome on a chip

Affiliations Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA, USA Roberta Poceviciute  & Rustem F. Ismagilov Division of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA, USA Rustem F. Ismagilov Corresponding author Correspondence to Rustem F....

Graphene Oxide increases mammalian spermatozoa fertilizing ability by extracting cholesterol from their membranes and...

1. Li, Z. et al. Field and temperature dependence of intrinsic diamagnetism in graphene: Theory and experiment. Phys. Rev. B 91, 094429 (2015). 2. Yoo, J. M., Kang, J. H. & Hong, B. H. Graphene-based nanomaterials for...

MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

1. Tang, F. et al. mRNA-Seq whole-transcriptome analysis of a single cell. Nat. Methods 6, 377–382 (2009). 2. Tang, F. et al. RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nat. Protoc. 5, 516–535...

Combining DNA and RNA Testing Could Improve Precision Medicine for Cancer

An international clinical trial has shown that extending cancer testing beyond genetic mutations has potential to improve the personalized treatment of cancer. In recent years, the field of precision medicine has been rapidly growing and...

Can Anti-Aging Research Keep Us Healthy in the Long Run?

Searching for the fountain of eternal youth has been the dream of humanity for millennia. While this is still in the realms of science fiction, anti-aging companies are hoping to tackle aging-related diseases by...

New technology developed for microscopic imaging in living organisms

Biotechnologists, physicists, and medical researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have developed technology for microscopic imaging in living organisms. A miniaturized multi-photon microscope, which could be used in an endoscope in future, excites the body's...

PiPred – a deep-learning method for prediction of π-helices in protein sequences

Construction of the training and test sets The Protein Data Bank structures, grouped into clusters comprising entries that share at least 50% sequence identity, were obtained from https://www.rcsb.org/pages/download/ftp (bc-50.out file). Structures longer than 700 or...

IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production

IκBζ−/− mice exhibit severe and chronic head and cervical inflammation, especially in aged mice17,22. Thus, they are widely used as an animal model of Sjögren syndrome22. One of the most common symptoms of Sjögren...

UK Scientists Open Bacterial Genome Up to Making Artificial Proteins

A research group from the University of Cambridge has created bacteria with less complexity in their genome, which could free up DNA code for producing synthetic proteins never before seen in nature. There are lots...

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