Dutch-US Scientists Use Bacteria to Produce Graphene for Electronics

An international group of researchers has made graphene more affordably and with a lower environmental impact than current chemical methods by using bacteria.    Graphene is a very strong and conductive material that could revolutionize electronics...

Using molecular biomarkers to guide the choice of therapies for metastatic pancreatic cancer

A new pilot study demonstrated the feasibility of using molecular tumor markers as the basis for selecting the chemotherapeutic agents to use in patients with metastatic pancreatic cancer. Based on these promising results a...

Plant Cells Eat Their Own … Membranes and Oil Droplets

Study IDs dual role for “autophagy”—a.k.a. “self-eating”—in building and breaking down plant oils. Manipulating the process could drive up oil accumulation in bioenergy crops. Changcheng Xu (rear, left), Linhui Yu, and Jilian Fan (seated) with...

Taking a Drug to Market “Is a Marathon, Not a Sprint”

Based in Zurich, Molecular Partners is developing a new class of drugs that can address the complexity of cancer. At Labiotech Refresh in Zurich, CEO Patrick Amstutz shared what he’s learned on the journey...

The possible involvement of oxidative stress in the oocyte ageing process in goldfish Carassius...

1. Liang, X., Ma, J., Schatten, H. & Sun, Q. Epigenetic changes associated with oocyte aging. Sci. China. Life. Sci. 55(8), 670–676 (2012). 2. Lahnsteiner, F., Urbanyi, B., Horvath, A. & Weismann, T. Bio-markers for egg quality...

Cutting-edge electron microscopy reveals first structures of a lipid-flippase

Using cutting-edge electron microscopy, researchers from Aarhus University have determined the first structures of a lipid-flippase. The discoveries provide a better understanding of the basics of how cells work and stay healthy, and can...

Epigenetic research provides new approaches to cancer combination therapies

Epigenetic processes enable cells to respond to changes in their environment by regulating the activity of their genes. One of the proteins that plays a key role in gene activation is BRD4, a well-characterized...

Protein-linked sugars are crucial for the uptake of proteins linked to Parkinson’s disease

Parkinson’s disease, a neurodegenerative disorder that affects more than 6 million people worldwide, is caused by the buildup of alpha-synuclein proteins in the brain. The biological function of alpha-synuclein is still not well understood,...

Update: Novartis’ Neurological Gene Therapy Receives FDA Approval

Update (24/05/2019): Zolgensma, developed by Novartis, has become the first FDA-approved gene therapy for the treatment of spinal muscular atrophy in patients under two years old. The gene therapy is also being reviewed under an...

Clinically-relevant postzygotic mosaicism in parents and children with developmental disorders in trio exome sequencing...

1. Biesecker, L. G. & Spinner, N. B. A genomic view of mosaicism and human disease. Nat. Rev. Genet. 14, 307–320 (2013). 2. Lupski, J. R. Genome mosaicism–one human, multiple genomes. Science 341, 358–359 (2013). 3. Acuna-Hidalgo, R. et...

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