PiPred – a deep-learning method for prediction of π-helices in protein sequences

Construction of the training and test sets The Protein Data Bank structures, grouped into clusters comprising entries that share at least 50% sequence identity, were obtained from https://www.rcsb.org/pages/download/ftp (bc-50.out file). Structures longer than 700 or...

ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion

Leech central nervous system structure All protocols regarding the use of leeches were carried out in strict accordance with the French legislation and European Treaty, and in compliance with the Helsinki Declaration. The adult leeches...

Drug for Autoimmune Liver Disease Yields Mixed Results in Hard-to-Treat Patients

Developed by the French biotech Genkyotex, a first-in-class treatment for the liver disease primary biliary cholangitis failed to reduce a key disease biomarker in a phase II trial, but showed potential for reducing liver...

Vaccination May Help Protect Bats from Deadly Disease

“This is a significant step forward in developing control mechanisms to combat the devastating spread of white-nose syndrome in our important bat populations,” said USGS Director Jim Reilly. “Being able to deliver an oral...

6 Tips on How to Choose the Best Software Solution for Your Biopharma Partnering

Biotechnology is booming. Everyone working in the life science industry knows it and the numbers say so too. By 2025, for instance, the global biotech market is estimated to reach $727Bn. But this fast-paced...

Children and teens who drink low-calorie sweetened beverages do not save calories

New study also shows kids and teens who consume low-calorie sweetened beverages take in more calories compared to those who drink water Credit: Matthew Golden WASHINGTON, D.C. (May...

Molecular-scale visualization and surface charge density measurement of Z-DNA in aqueous solution

1. Watson, J. D. & Crick, F. H. C. Molecular Structure of Nucleic Acids. Nature 171, 737–738 (1953). 2. Zhao, J., Bacolla, A., Wang, G. & Vasquez, K. M. Non-B DNA structure-induced genetic instability and evolution. Cell....

Still Looking for a Job? We Got Your Back!

Hello biotechnologists,Job hunt frustrating? Don’t worry, we’re here to help. Check out the position as Senior Scientist at AbbVie or become a Sales Specialist at Merck. Just starting out? Check out the internship at Roche! Research...

Searching for lost WWII-era uranium cubes from Germany

University of Maryland researchers are piecing together what exactly happened to hundreds of cubes of uranium from a secretive and ultimately failed effort to build a working nuclear reactor in Nazi Germany during World...

Author Correction: Engineering of high-precision base editors for site-specific single nucleotide replacement

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit...

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