Austrian Biotech Raises €19M to Commercialize First Chikungunya Vaccine

The market is in sight for the first potential vaccine for the chikungunya virus, as the company Themis Bioscience will receive up to €18.7M ($21M) in non-dilutive funding to finance the vaccine’s phase III...

Double success for innovative ‘child-friendly’ HIV treatment

University of Liverpool’s Nanomedicine research has been recognised by The (US) President’s Emergency Plan for AIDS Relief and a fundraising campaign to help improve drug therapies for children with HIV has reached its target...

Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens

Synthesis of the amSPCs Compounds 1950, 1951, 2241, and 2324 were synthesized according to the procedure reported previously . The purity and identity of the compounds was determined using reverse phase Ultra-Performance Liquid Chromatography (UPLC)...

An effective sweeper closes DNA replication cycling

ATAD5-RLC unloads PCNA to cut off genetic mutations Credit: IBS DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA...

Dutch Company Raises €28M to Push Cancer Cell Therapy to European Market

The Dutch Kiadis Pharma has raised €27.6M in a private placement to fund the clinical development of immune cell therapies treating blood cancer. The money will fund phase III trials of Kiadis’ lead candidate cell...

More than half of patients in pain management study took no opioids after operations

The opioid epidemic has become a public health crisis in the U.S. While primary care physicians have been writing fewer opioid prescriptions over the last several years, new opioid prescriptions by surgeons increased 18...

Body’s endocannabinoid system appears to be new target for drug development against OCD

The body's endocannabinoid system, due to the critical role it plays in regulating neurotransmitter signaling, is an enticing target for drug development against disorders associated with anxiety, stress, and repetitive behaviors, such as obsessive-compulsive...

Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy

Ethical statement The University of New Mexico (UNM) Institutional Animal Care and Use Committee (IACUC) approved (IACUC protocol #s: 19-200841-B-HSC (Breeding); 18-200761-HSC (Experimental)) all animal procedures described in the study. Human brain tissue samples Human frontotemporal dementia...

Enzalutamide improves survival for men with metastatic hormone-sensitive prostate cancer

Credit: Dana-Farber Cancer Institute After 3 years, 80% of men with metastatic hormone-sensitive prostate cancer who received enzalutamide along with testosterone suppression were alive compared to 72%...

Ribociclib plus hormone therapy extends survival for patients with premenopausal advanced hormone receptor-positive breast...

MD Anderson-led Phase III trial finds targeted therapy lowers risk of death, is well-tolerated Credit: MD Anderson Cancer Center ABSTRACT LBA1008 Adding the targeted therapy ribociclib to hormone therapy...

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