Study revealing the secret behind a key cellular process refutes biology textbooks

New research has identified and described a cellular process that, despite what textbooks say, has remained elusive to scientists until now – precisely how the copying of genetic material that, once started, is properly...

Researchers study the role of viral intramebrane interactions in controlling programmed cell death

A research group from the Department of Biochemistry and Molecular Biology of the University of Valencia (UV), in coordination with the National Centre for Biotechnology (CNB) of the CSIC, has studied the role of...

Electronic skin has a strong future stretching ahead

Credit: © 2020 KAUST A material that mimics human skin in ?strength, stretchability and sensitivity could be used to collect biological data in real time. Electronic skin,...

uniQure Stocks Up With First Phase III Results of Hemophilia B Gene Therapy

Gene therapies for the rare blood clotting disorder hemophilia B have taken a step closer to the market as Dutch developer uniQure became the first to release interim phase III results last week. Hemophilia is...

Gene analysis may increase the effect of antidepressant and antipsychotic drugs

In a new study published in the journal JAMA Psychiatry, researchers at Karolinska Institutet have studied CYP2C19 and CYP2D6 genes impact on treatment with antidepressants and antipsychotic drugs. The study shows that control of...

Novel homozygous variant in the TPO gene associated with congenital hypothyroidism and mild-intellectual disability

Congenital hypothyroidism (CH) is diagnosed as thyroid hormone deficiency in newborn infants with an incidence of 1:2000 to 1:4000 live births worldwide1. Approximately 80–85% of CH cases are associated with thyroid dysgenesis (TD); either...

Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

Materials and reagents The phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- (DSPE-mPEG2000), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- (DSPE-PEG(2000)-succinyl) were purchased from Avanti Polar Lipids, Inc. (Alabaster, AL). Cholesterol (Chol), N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC), and N-Hydroxysuccinimide (NHS) were purchased from Sigma-Aldrich (St. Louis,...

Irreversible hotter and drier climate over inner East Asia

Heatwaves pushing Mongolia’s climate to a tipping point Credit: Ken Shono, Unsplash Mongolia’s semi-arid plateau may soon become as barren as parts of the American Southwest due to...

AstraZeneca’s Covid-19 Vaccine Proves Its Worth in Phase III

A much anticipated Covid-19 vaccine, developed by the University of Oxford and AstraZeneca, achieved 70% efficacy in phase III interim data. While less effective on paper, it could prove cheaper and easier to distribute...

Stem cell study identifies enzyme with potential for cancer treatment

The study, published by University of Alberta biologists, identifies an inhibition mechanism of an enzyme called Myt1 kinase, which manages how stem cells develop and differentiate during organ development in fruit flies. Image credit: Jim...

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